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KMID : 0383119990460010043
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Journal of Aerospace Medicine
1999 Volume.46 No. 1 p.43 ~ p.54
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Postischemic Apoptosis in Mongolian Gerbil Brain
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Jung Kyeong-Cheon
Kim In-Byung
Yim Sung-Vin
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Abstract
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Ischemic insult is one of the physiologic problems encountered at high altitude. Short-term exposure induce transient disturbance in brain function but organic changes occurs after long-term hypoxia and reperfusion. In this work, the time course and localization of ischemic neuronal damage and apoptotic changes in the Mongolian gerbil mode1 of ischemia were assessed. By light microscopy, ischemic neuronal damage were detected in the hippocampal CA1 pyramidal layer 3 day after transient ischemic insult, which showed chromosomal condensation and cytoplasmic eosinophilia. Ischemic neuronal cells were increased in the CA1 region on day 5. More nuclei of the CA1 neurons than
ischemic neurons seen by light microscopy were nick-end labeled by digoxigenin-conjugated dUTP mediated by terminal deoxytransferase 3 and 5 days after ischemic insult. These results suggest that delayed death of the CA1 pyramidal neuron after short-term ischemic insult is induced by apoptotic mechanism.
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KEYWORD
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Hypoxia, Mongolian gerbil, hippocampal, apoptosis
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